Marfan Syndrome Body Ratio Analyzer

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Marfan Syndrome Calculator: Understanding Your Body’s Clues

What Is Marfan Syndrome?

Marfan syndrome is a genetic disorder affecting connective tissues, with characteristic features like:

• Abnormally long limbs

• Cardiovascular complications

• Skeletal irregularities
  Early detection through anthropometric measurements can prevent life-threatening complications like aortic dissection.

Why Body Ratios Matter in Diagnosis

Key Parameters Measured

1. Arm Span/Height Ratio

   • Definition: Comparison between fingertip-to-fingertip arm span and total height

   • Significance: Ratio >1.05 suggests Marfan predisposition

2. Hand/Height Ratio

   • Definition: Hand length divided by height

   • Threshold: >11% indicates abnormal proportions

3. Thumb Sign (Walker-Murdoch Test)

   • Method: Thumb protrudes beyond clenched fist

   • Clinical Value: Present in 65-70% of Marfan patients

How the Marfan Syndrome Calculator Works

Input Parameters

The calculator evaluates:

• Anthropometric Data (Height, Arm Span, Hand/Foot Length)

• Clinical Features (Pectus deformity, Scoliosis, Eye lens dislocation)

• Family History

Scoring System

FeatureScore RangeBody Ratios0-7 pointsSystemic Manifestations0-9 pointsFamily History0-3 points

Interpreting Your Results

Risk Categories

1. Low Risk (0-6 Points)

   • Green zone on meter

   • No immediate action needed

2. Moderate Risk (7-14 Points)

   • Yellow zone

   • Recommend echocardiogram

3. High Risk (15+ Points)

   • Red zone

   • Urgent genetic testing advised

Limitations & Next Steps

While this calculator uses Ghent II criteria, it cannot replace:

1. Echocardiograms

2. FBN1 gene testing

3. Ophthalmologic exams

FAQs

Q: Can children use this calculator?
A: Yes, but z-scores for pediatric patients will auto-adjust.

Q: What’s considered a ‘positive’ thumb sign?
A: If >50% of the nail extends beyond the fist.