Carboplatin Dose Calculator

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Free Carboplatin Dose Calculator - Optimize Chemotherapy Treatment

Carboplatin is a platinum-based chemotherapy drug used to treat various cancers, including ovarian, lung, and testicular cancers. Unlike traditional medications, chemotherapy dosing requires precision to balance efficacy against potentially life-threatening side effects.

Key Clinical Parameters in Carboplatin Dosing

1. Creatinine Clearance (CrCl)
   Measures kidney function through serum creatinine levels. Since carboplatin is primarily renally excreted, impaired kidney function increases toxicity risks.

2. Target AUC (Area Under the Curve)
   Represents drug exposure over time (measured in mg/mL/min). Standard ranges:

   Cancer TypeTypical AUC RangeOvarian Cancer5-7Lung Cancer4-6Pediatric Cancers4-7

3. Body Surface Area (BSA)
   Calculated from height/weight using formulas like Mosteller:
   BSA (m²) = √(height(cm) × weight(kg) / 3600)

How the Calculator Works: The Calvert Formula

Our tool applies the evidence-based Calvert Formula:
Carboplatin Dose (mg) = Target AUC × (CrCl + 25)

Example Calculation:

• Target AUC: 6

• Creatinine Clearance: 80 mL/min

• Dose = 6 × (80 + 25) = 630 mg

Clinical Applications

Diagnosis & Treatment Planning
Carboplatin is typically prescribed after:

• Histopathological confirmation of malignancy

• CT/MRI staging scans

• Renal function assessment (eGFR testing)

Side Effect Management
Common toxicities requiring dose adjustments:

• Myelosuppression (low platelets/white blood cells)

• Nephrotoxicity

• Neuropathy

• Hypersensitivity reactions

Precautionary Measures

• Hydration protocols (1-2L IV fluids pre/post-infusion)

• Anti-emetics for nausea control

• Regular CBC monitoring (weekly)

Interpreting Calculator Results

1. Green Range (400-750 mg)
   Optimal dosing for most adults with normal renal function

2. Yellow Range (300-400 mg or 750-900 mg)
   Requires re-evaluation of creatinine clearance

3. Red Range (<300 mg or >900 mg)
   High toxicity risk - consult oncology team immediately

FAQs: Carboplatin Chemotherapy

Q: How often is carboplatin administered?
A: Typically every 3-4 weeks depending on cancer type and regimen.

Q: Can carboplatin be used in renal impairment?
A: Dose reductions required when CrCl <60 mL/min - never administer below CrCl 20 mL/min.

Q: What drugs interact with carboplatin?
A: Aminoglycosides (increased nephrotoxicity), phenytoin (reduced efficacy), and live vaccines.

Disclaimer: This calculator provides initial dosing estimates only. Actual chemotherapy regimens must be prescribed by qualified oncologists based on comprehensive clinical evaluation.